Reina Engle-Stone, Ph.D.

Education

• B.A., Cornell University, Ithaca, New York
• Ph.D., University of California, Davis

Research Interests

Dr. Engle-Stone's research is in global public health nutrition, with a focus on micronutrient nutrition among women and young children in low-income settings. Research themes include planning, monitoring, and evaluation of food fortification programs; cost-effectiveness and coherence among micronutrient intervention programs, and nutritional assessment.

Selected Publications

Full list of publications available here: https://www.ncbi.nlm.nih.gov/sites/myncbi/1beLvasEYhvAg/bibliography/40315043/public/

Engle-Stone R, Miller JC, Reario MFD, Arnold CD, Stormer A, Lafuente E, Oxley A, Capanzana MV, Cabanilla CVD, Ford JL, Clark A, Velavan TP, Brown KH, Lietz G, Haskell MJ. Filipino Children with High Usual Vitamin A Intakes and Exposure to Multiple Sources of Vitamin A Have Elevated Total Body Stores of Vitamin A But Do Not Show Clear Evidence of Vitamin A Toxicity. Curr Dev Nutr. 2022 Jul 25;6(8):nzac115. doi: 10.1093/cdn/nzac115.

Johnson CM, Rosario R, Brito A, Agrawal K, Fanter R, Lietz G, Haskell M, Engle-Stone R, Newman JW, La Frano MR. Multiassay nutritional metabolomics profiling of low vitamin A status versus adequacy is characterized by reduced plasma lipid mediators among lactating women in the Philippines: A pilot study. Nutr Res. 2022 Aug;104:118-127. doi: 10.1016/j.nutres.2022.05.007.

Olivares LV, Engle-Stone R, Arnold CD, Langer CE, Schenker MB. Anemia, Weight Status, and Fatigue Among Farmworkers in California: A Cross-Sectional Study. J Occup Environ Med. 2022 Aug 1;64(8):e459-e466. doi: 10.1097/JOM.0000000000002578.

luo H, Dodd KW, Arnold CD, Engle-Stone R. Advanced dietary analysis and modeling: a deep dive into the National Cancer Institute method. J Nutr. 2022 Jun 29:nxac144. doi: 10.1093/jn/nxac144.

Adams KP, Vosti SA, Mbuya MNN, Friesen VM, Engle-Stone R. Update on Analytical Methods and Research Gaps in the Use of Household Consumption and Expenditure Survey Data to Inform the Design of Food-Fortification Programs. Adv Nutr. 2022 Jun 1;13(3):953-969. doi: 10.1093/advances/nmac021.

Adams KP, Luo H, Vosti SA, Kagin J, Ngnie-Teta I, Ndjebayi A, Assiene JG, Engle-Stone R. Comparing estimated cost-effectiveness of micronutrient intervention programs using primary and secondary data: evidence from Cameroon. Ann N Y Acad Sci. 2022 Apr;1510(1):100-120. doi: 10.1111/nyas.14726.

Matthias D, McDonald CM, Archer N, Engle-Stone R. The Role of Multiply-Fortified Table Salt and Bouillon in Food Systems Transformation. Nutrients. 2022 Feb 26;14(5):989. doi: 10.3390/nu14050989.

Haile D, Brown KH, McDonald CM, Luo H, Jarvis M, Teta I, Ndjebayi A, Martial GAJ, Vosti SA, Engle-Stone R. Applying Zinc Nutrient Reference Values as Proposed by Different Authorities Results in Large Differences in the Estimated Prevalence of Inadequate Zinc Intake by Young Children and Women and in Cameroon. Nutrients. 2022 Feb 19;14(4):883. doi: 10.3390/nu14040883.

Noshirvan A, Wu B, Luo H, Kagin J, Vosti SA, Ndjebayi A, Assiene JG, Teta I, Nankap M, Engle-Stone R. Predicted Effects and Cost-Effectiveness of Wheat Flour Fortification for Reducing Micronutrient Deficiencies, Maternal Anemia, and Neural Tube Defects in Yaoundé and Douala, Cameroon. Food Nutr Bull. 2021 Dec;42(4):551-566. doi: 10.1177/03795721211020716.

Luo H, Brown KH, Stewart CP, Beckett LA, Clermont A, Vosti SA, Guintang Assiene JM, Engle-Stone R. Review of Existing Models to Predict Reductions in Neural Tube Defects Due to Folic Acid Fortification and Model Results Using Data from Cameroon. Adv Nutr. 2021 Dec 1;12(6):2401-2414. doi: 10.1093/advances/nmab083.

Oxley A, Engle-Stone R, Miller JC, Reario MFD, Stormer A, Capanzana MV, Cabanilla CVD, Haskell MJ, Lietz G. Determination of Vitamin A Total Body Stores in Children from Dried Serum Spots: Application in a Low- and Middle-Income Country Community Setting. J Nutr. 2021 May 11;151(5):1341-1346. doi: 10.1093/jn/nxaa446.

Luo H, Dodd KW, Arnold CD, Engle-Stone R. Introduction to the SIMPLE Macro, a Tool to Increase the Accessibility of 24-Hour Dietary Recall Analysis and Modeling. J Nutr. 2021 May 11;151(5):1329-1340. doi: 10.1093/jn/nxaa440.

French CD, Arsenault JE, Arnold CD, Haile D, Luo H, Dodd KW, Vosti SA, Slupsky CM, Engle-Stone R; Variance Components of Nutrient Intakes Data Working Group. Within-Person Variation in Nutrient Intakes across Populations and Settings: Implications for the Use of External Estimates in Modeling Usual
Nutrient Intake Distributions. Adv Nutr. 2021 Mar 31;12(2):429-451. doi: 10.1093/advances/nmaa114.

Haile D, Luo H, Vosti SA, Dodd KW, Arnold CD, Engle-Stone R. Micronutrient Fortification of Commercially Available Biscuits Is Predicted to Have Minimal Impact on Prevalence of Inadequate Micronutrient Intakes: Modeling of National Dietary Data From Cameroon.Curr Dev Nutr. 2020 Aug 10;4(9):nzaa132. doi: 10.1093/cdn/nzaa132.

Davis JN, Oaks BM, Engle-Stone R. The Double Burden of Malnutrition: A Systematic Review of Operational Definitions. Curr Dev Nutr. 2020 Jul 21;4(9):nzaa127. doi: 10.1093/cdn/nzaa127.

Vosti SA, Kagin J, Engle-Stone R, Luo H, Tarini A, Clermont A, Assiene JG, Nankap M, Brown KH. Strategies to achieve adequate vitamin A intake for young children: options for Cameroon. Ann N Y Acad Sci. 2020 Apr;1465(1):161-180. doi: 10.1111/nyas.14275.

Luo H, Dodd KW, Arnold CD, Engle-Stone R. A New Statistical Method for Estimating Usual Intakes of Nearly-Daily Consumed Foods and Nutrients Through Use of Only One 24-hour Dietary Recall. J Nutr. 2019 Sep 1;149(9):1667-1673. doi: 10.1093/jn/nxz070.

Williams AM, Guo J, Addo OY, Ismaily S, Namaste SML, Oaks BM, Rohner F, Suchdev PS, Young MF, Flores-Ayala R, Engle-Stone R. Intraindividual double burden of overweight or obesity and micronutrient deficiencies or anemia among women of reproductive age in 17 population-based surveys. Am J Clin Nutr. 2019 Aug 1;112(Suppl 1):468S-477S. doi: 10.1093/ajcn/nqaa118.

Engle-Stone R, Guo J, Ismaily S, Addo OY, Ahmed T, Oaks B, Suchdev PS, Flores-Ayala R, Williams AM. Intraindividual double burden of overweight and micronutrient deficiencies or anemia among preschool children. Am J Clin Nutr. 2019 Aug 1;112(Suppl 1):478S-487S. doi: 10.1093/ajcn/nqaa101.

Mark HE, Assiene JG, Luo H, Nankap M, Ndjebayi A, Ngnie-Teta I, Tarini A, Pattar A, Killilea DW, Brown KH, Engle-Stone R. Monitoring of the National Oil and Wheat Flour Fortification Program in Cameroon Using a Program Impact Pathway Approach.Curr Dev Nutr. 2019 Jun 20;3(8):nzz076. doi:10.1093/cdn/nzz076.

Engle-Stone R, Vosti SA, Luo H, Kagin J, Tarini A, Adams KP, French C, Brown KH. Weighing the risks of high intakes of selected micronutrients compared with the risks of deficiencies. Ann NY Acad Sci. 2019 Jun;1446(1):81-101. doi: 10.1111/nyas.14128.

Engle-Stone R, Perkins A, Clermont A, Walker N, Haskell MJ, Vosti SA, Brown KH. Estimating Lives Saved by Achieving Dietary Micronutrient Adequacy, with a Focus on Vitamin A Intervention Programs in Cameroon. J Nutr. 2017 Sep 13. pii: jn242271. [PubMed]

Kuyper EM, Engle-Stone R, Arsenault JE, Arimond M, Adams KP, Dewey KG. Dietary gap assessment: an approach for evaluating whether a country's food supply can support healthy diets at the population level. Public Health Nutr. 2017 Sep;20(13):2277-2288. [PubMed]

Engle-Stone R, Williams TN, Nankap M, Ndjebayi A, Gimou MM, Oyono Y, Tarini A, Brown KH, Green R. Prevalence of Inherited Hemoglobin Disorders and Relationships with Anemia and Micronutrient Status among Children in Yaoundé and Douala, Cameroon. Nutrients. 2017 Jul 3;9(7). pii: E693. [PubMed]

Wirth JP, Woodruff BA, Engle-Stone R, Namaste SM, Temple VJ, Petry N, Macdonald B, Suchdev PS, Rohner F, Aaron GJ. Predictors of anemia in women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. Am J Clin Nutr. 2017 Jul;106(Suppl 1):416S-427S. [PubMed]

Engle-Stone R, Aaron GJ, Huang J, Wirth JP, Namaste SM, Williams AM, Peerson JM, Rohner F, Varadhan R, Addo OY, Temple V, Rayco-Solon P, Macdonald B, Suchdev PS. Predictors of anemia in preschool children: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. Am J Clin Nutr. 2017 Jul;106(Suppl 1):402S-415S. [PubMed]

Larson LM, Namaste SM, Williams AM, Engle-Stone R, Addo OY, Suchdev PS, Wirth JP, Temple V, Serdula M, Northrop-Clewes CA. Adjusting retinol-binding protein concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. Am J Clin Nutr. 2017 Jul;106(Suppl 1):390S-401S. [PubMed]

Engle-Stone R, Nankap M, Ndjebayi AO, Allen LH, Shahab-Ferdows S, Hampel D, Killilea DW, Gimou MM, Houghton LA, Friedman A, Tarini A, Stamm RA, Brown KH. Iron, Zinc, Folate, and Vitamin B-12 Status Increased among Women and Children in Yaoundé and Douala, Cameroon, 1 Year after Introducing Fortified Wheat Flour. J Nutr. 2017 Jul;147(7):1426-1436. [PubMed]

Engle-Stone R, Nankap M, Ndjebayi A, Gimou MM, Friedman A, Haskell MJ, Tarini A, Brown KH. Vitamin A Status of Women and Children in Yaoundé and Douala, Cameroon, is Unchanged One Year after Initiation of a National Vitamin A Oil Fortification Program. Nutrients. 2017 May 20;9(5). pii: E522. [PubMed]

Bruins MJ, Kupka R, Zimmermann MB, Lietz G, Engle-Stone R, Kraemer K. Maximizing the benefits and minimizing the risks of intervention programs to address micronutrient malnutrition: symposium report. Matern Child Nutr. 2016 Aug 9. [PubMed]

Klemm RD, Palmer AC, Greig A, Engle-Stone R, Dalmiya N. A Changing Landscape for Vitamin A Programs: Implications for Optimal Intervention Packages, Program Monitoring, and Safety. Food Nutr Bull. 2016 Jun;37(2 Suppl):S75-86. [PubMed]

S, Engle-Stone R, Hampel D, Ndjebayi AO, Nankap M, Brown KH, Allen LH. Regional, Socioeconomic, and Dietary Risk Factors for Vitamin B-12 Deficiency Differ from Those for Folate Deficiency in Cameroonian Women and Children. J Nutr. 2015 Nov;145(11):2587-95. [PubMed]

Vosti SA, Kagin J, Engle-Stone R, Brown KH. An Economic Optimization Model for Improving the Efficiency of Vitamin A Interventions: An Application to Young Children in Cameroon. Food Nutr Bull. 2015 Sep;36(Suppl 3):S193-207. [PubMed]

Brown KH, Engle-Stone R, Kagin J, Rettig E, Vosti SA. Use of Optimization Modeling for Selecting National Micronutrient Intervention Strategies: An Example Based on Potential Programs for Control of Vitamin A Deficiency in Cameroon. Food Nutr Bull. 2015 Sep;36(Suppl 3):S141-8. [PubMed]

Kagin J, Vosti SA, Engle-Stone R, Rettig E, Brown KH, Nankap M, Ndjebayi A. Measuring the Costs of Vitamin A Interventions: Institutional, Spatial, and Temporal Issues in the Context of Cameroon. Food Nutr Bull. 2015 Sep;36(Suppl 3):S172-92. [PubMed]

Engle-Stone R, Nankap M, Ndjebayi AO, Vosti SA, Brown KH. Estimating the Effective Coverage of Programs to Control Vitamin A Deficiency and Its Consequences Among Women and Young Children in Cameroon. Food Nutr Bull. 2015 Sep;36(Suppl 3):S149-71. [PubMed]

Engle-Stone R, Brown KH. Comparison of a household income and expenditure survey with nationally-representative food frequency and 24-hour recall dietary data for assessing consumption of fortifiable foods by women and young children. 2015 Jun;36(2):211-30. Food Nutr Bull. [PubMed]

Bielderman I, Bruins MJ, Engle-Stone R, Solomons NW, Verhagen H, Allen LH, Kraemer K, Badham J. Symposium report: Effective and safe micronutrient interventions, weighing the risks against the benefits. Eur J Nutr Food Safety. 2015; 5(4): 202-228. [Article]

Engle-Stone R, Nankap M, Ndjebayi A, Brown KH. Simulations based on representative 24 h recall data predict region-specific differences in adequacy of vitamin A intake among Cameroonian women and young children following large-scale fortification of vegetable oil and other potential food vehicles. J Nutr. 2014 Nov; 144(11): 1826034. [PubMed]

Engle-Stone R, Haskell MJ, La Frano MR, Ndjebayi AO, Nankap M, Brown KH. Comparison of breast milk vitamin A concentration measured by a rapid field assay in fresh milk with standard measurement of frozen samples by HPLC. Eur J Clin Nutr. 2014 Aug; 68(8):938-40. [PubMed]

Engle-Stone R, Nankap M, Ndjebayi AO, Killilea DW, Brown KH. Stunting prevalence, plasma zinc concentrations, and dietary zinc intakes in a nationally-representative sample suggest a high risk of zinc deficiency among women and young children in Cameroon. J Nutr. 2014 Mar; 144(3):382-91. [PubMed]

Engle-Stone R, Haskell MJ, Nankap M, Ndjebayi AO, Brown KH. Breast milk vitamin A concentration and plasma retinol-binding protein provide similar estimates of vitamin A deficiency and identify similar risk groups among women in Cameroon, but breast milk retinol underestimates the prevalence of vitamin A deficiency among young children. J Nutr. 2014 Feb; 144(2):209-17. [PubMed]

Hess SY, Brown KH, Sablah M, Engle-Stone R, Aaron GJ, Baker SA. Results of Fortification Rapid Assessment Tool (FRAT) surveys in sub-Saharan Africa and suggestions for future modifications of the survey instrument. Food Nutr Bull. 2013 Mar; 34(1):21-38. [PubMed]

Engle-Stone R, Nankap M, Ndjebayi A, Erhardt JG, Brown KH. Plasma ferritin, soluble transferrin receptor, and body iron stores identify similar risk factors for iron deficiency but result in different estimates of the national prevalence of iron deficiency and iron-deficiency anemia in Cameroon. J Nutr. 2013 Mar; 143(3):369-77. [PubMed]

Engle-Stone R, Ndjebayi A, Nankap M, Brown KH. Consumption of potentially fortifiable foods by women and young children varies by ecological zone and socio-economic status in Cameroon. J Nutr. 2012; 142(3):555-65. [PubMed]

Engle-Stone R, Haskell MJ, Ndjebayi A, Nankap M, Erhardt JG, Gimou MM, Brown KH. Plasma retinol-binding protein predicts plasma retinol in infected and uninfected Cameroonian women and children. J Nutr. 2011; 141(12):2233-41. [PubMed]

Brown KH, Engle-Stone R, Krebs NF, Peerson JM. Dietary intervention strategies to enhance zinc nutrition: Promotion and support of breast feeding for infants and young children. Food Nutr Bull. 2009; 30 (1 Suppl):S142-69. [PubMed]

Engle-Stone R, Yeung A, Welch RM, Glahn RP. Meat and ascorbic acid can promote Fe availability from Fe-phytate but not from Fe-tannic acid complexes. J Agric Food Chem. 2005; 53 (26):10276-84. [PubMed]

Bruins MJ, Kupka R, Zimmermann MB, Lietz G, Engle-Stone R, Kraemer K. Maximizing the benefits and minimizing the risks of intervention programs to address micronutrient malnutrition: symposium report. Matern Child Nutr. 2016 Aug 9. [PubMed]

Klemm RD, Palmer AC, Greig A, Engle-Stone R, Dalmiya N. A Changing Landscape for Vitamin A Programs: Implications for Optimal Intervention Packages, Program Monitoring, and Safety. Food Nutr Bull. 2016 Jun;37(2 Suppl):S75-86.  [PubMed]

Shahab-Ferdows S, Engle-Stone R, Hampel D, Ndjebayi AO, Nankap M, Brown KH, Allen LH.  Regional, Socioeconomic, and Dietary Risk Factors for Vitamin B-12 Deficiency Differ from Those for Folate Deficiency in Cameroonian Women and Children. J Nutr. 2015 Nov;145(11):2587-95.   [PubMed]

Vosti SA, Kagin J, Engle-Stone R, Brown KH. An Economic Optimization Model for Improving the Efficiency of Vitamin A Interventions: An Application to Young Children in Cameroon. Food Nutr Bull. 2015 Sep;36(Suppl 3):S193-207. [PubMed]

Brown KH, Engle-Stone R, Kagin J, Rettig E, Vosti SA. Use of Optimization Modeling for Selecting National Micronutrient Intervention Strategies: An Example Based on Potential Programs for Control of Vitamin A Deficiency in Cameroon. Food Nutr Bull. 2015 Sep;36(Suppl 3):S141-8. [PubMed]

Kagin J, Vosti SA, Engle-Stone R, Rettig E, Brown KH, Nankap M, Ndjebayi A. Measuring the Costs of Vitamin A Interventions: Institutional, Spatial, and Temporal Issues in the Context of Cameroon. Food Nutr Bull. 2015 Sep;36(Suppl 3):S172-92. [PubMed]

Engle-Stone R, Nankap M, Ndjebayi AO, Vosti SA, Brown KH.  Estimating the Effective Coverage of Programs to Control Vitamin A Deficiency and Its Consequences Among Women and Young Children in Cameroon. Food Nutr Bull. 2015 Sep;36(Suppl 3):S149-71. [PubMed]

Engle-Stone R, Brown KH. Comparison of a household income and expenditure survey with nationally-representative food frequency and 24-hour recall dietary data for assessing consumption of fortifiable foods by women and young children. 2015 Jun;36(2):211-30. Food Nutr Bull. [PubMed]

Bielderman I, Bruins MJ, Engle-Stone R, Solomons NW, Verhagen H, Allen LH, Kraemer K, Badham J. Symposium report: Effective and safe micronutrient interventions, weighing the risks against the benefits. Eur J Nutr Food Safety. 2015; 5(4): 202-228. [Article]

Engle-Stone R, Nankap M, Ndjebayi A, Brown KH. Simulations based on representative 24 h recall data predict region-specific differences in adequacy of vitamin A intake among Cameroonian women and young children following large-scale fortification of vegetable oil and other potential food vehicles. J Nutr. 2014 Nov; 144(11): 1826034. [PubMed]

Engle-Stone R, Haskell MJ, La Frano MR, Ndjebayi AO, Nankap M, Brown KH. Comparison of breast milk vitamin A concentration measured by a rapid field assay in fresh milk with standard measurement of frozen samples by HPLC. Eur J Clin Nutr. 2014 Aug; 68(8):938-40. [PubMed]

Engle-Stone R, Nankap M, Ndjebayi AO, Killilea DW, Brown KH. Stunting prevalence, plasma zinc concentrations, and dietary zinc intakes in a nationally-representative sample suggest a high risk of zinc deficiency among women and young children in Cameroon. J Nutr. 2014 Mar; 144(3):382-91. [PubMed]

Engle-Stone R, Haskell MJ, Nankap M, Ndjebayi AO, Brown KH. Breast milk vitamin A concentration and plasma retinol-binding protein provide similar estimates of vitamin A deficiency and identify similar risk groups among women in Cameroon, but breast milk retinol underestimates the prevalence of vitamin A deficiency among young children. J Nutr. 2014 Feb; 144(2):209-17. [PubMed]

Hess SY, Brown KH, Sablah M, Engle-Stone R, Aaron GJ, Baker SA. Results of Fortification Rapid Assessment Tool (FRAT) surveys in sub-Saharan Africa and suggestions for future modifications of the survey instrument. Food Nutr Bull. 2013 Mar; 34(1):21-38. [PubMed]

Engle-Stone R, Nankap M, Ndjebayi A, Erhardt JG, Brown KH. Plasma ferritin, soluble transferrin receptor, and body iron stores identify similar risk factors for iron deficiency but result in different estimates of the national prevalence of iron deficiency and iron-deficiency anemia in Cameroon. J Nutr. 2013 Mar; 143(3):369-77. [PubMed]

Engle-Stone R, Ndjebayi A, Nankap M, Brown KH.   Consumption of potentially fortifiable foods by women and young children varies by ecological zone and socio-economic status in Cameroon. J Nutr. 2012; 142(3):555-65. [PubMed]

Engle-Stone R, Haskell MJ, Ndjebayi A, Nankap M, Erhardt JG, Gimou MM, Brown KH. Plasma retinol-binding protein predicts plasma retinol in infected and uninfected Cameroonian women and children. J Nutr. 2011; 141(12):2233-41. [PubMed]

Brown KH, Engle-Stone R, Krebs NF, Peerson JM. Dietary intervention strategies to enhance zinc nutrition: Promotion and support of breast feeding for infants and young children. Food Nutr Bull. 2009; 30 (1 Suppl):S142-69. [PubMed]

Engle-Stone R, Yeung A, Welch RM, Glahn RP. Meat and ascorbic acid can promote Fe availability from Fe-phytate but not from Fe-tannic acid complexes. J Agric Food Chem. 2005; 53 (26):10276-84. [PubMed]