Peter J. Havel, Ph.D.

Education

• B.S., Zoology, University of Washington, Seattle
• D.V.M., School of Veterinary Medicine, University of California, Davis
• Ph.D., Endocrinology, Graduate Group in Endocrinology, University of California, Davis (Area of specialization - Pharmacology)

Research Interests

Dr. Peter Havel received a Doctorate of Veterinary Medicine (D.V.M.) and a Ph.D. in Endocrinology from the University of California at Davis. He is a currently a Professor with joint appointments in the Departments of Molecular Biosciences and Nutrition. Dr. Havel is investigating the regulation of energy homeostasis and carbohydrate/lipid metabolism, and the involvement of endocrine systems in the pathophysiology of obesity, diabetes, and cardiovascular disease. His laboratory is studying the mechanisms regulating the secretion of pancreatic and gastrointestinal hormones and the production of the adipocyte hormones, including leptin and adiponectin. Biochemical and molecular studies are conducted using in vitro systems and the role of endocrine, metabolic, and dietary factors in regulating energy balance, insulin action, and lipid/carbohydrate metabolism is examined in vivo in animals and humans. A major focus of the research is the interaction of diet composition (such as dietary fat and fructose) with the endocrine regulation of energy balance in the development and progression of obesity, diabetes, and dyslipidemia/atherosclerosis, including studies in animal models and clinical studies in humans. His research team is conducting studies on the prevention and treament of diabetes in a new rat model of type 2 diabetes developed in his laboratory. Dr. Havel and his collaborators are also investigating the effects of bariatric surgery procedures on gastrointestinal, pancreatic and adipocyte hormones and how these endocrine changes are involved in the improvements of carbohydrate and lipid metabolism observed after bariatiric surgery.

Professional Membership

• American Diabetes Association
• American Physiological Society
• American Society for Clinical Nutrition
• American Society for Nutritional Sciences
• American Society for Metabolic and Bariatric Surgery
• The Endocrine Society
• The Obesity Society

Editorial Boards

• Journal of Clinical Endocrinology and Metabolism
• Endocrinology
• American Journal of Clinical Nutrition
• Molecular Metabolism - Associate Editor for Translational Nutrition Biology
• Journal of Physiology and Biochemistry - Executive Editor for Endocrine Physiology

Awards

• Outstanding Investigator Award, American Federation for Medical Research (1999)
• Shih-Chun Wang Award for excellence in physiology research - American Physiological Society (2000)
• Academic Federation Award for Excellence in Research, University of California, Davis (2003)
• Professional Award for original research in Human Nutrition from Grupo Bimbo Panamericano (Mexico City, 2007)
• Pfizer Visiting Professor in Obesity (2009)

Selected Publications

Stanhope KL, Goran MI, Bosy-Westphal A, King JC, Schmidt LA, Schwarz JM, Stice E, Sylvetsky AC, Turnbaugh PJ, Bray GA, Gardner CD, Havel PJ, Malik V, Mason AE, Ravussin E, Rosenbaum M, Welsh JA, Allister-Price C, Sigala DM, Greenwood MRC, Astrup A, Krauss RM. Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories. Obes Rev. 2018 May 14. [PubMed]

Purnell JQ, Johnson GS, Wahed AS, Dalla Man C, Piccinini F, Cobelli C, Prigeon RL, Goodpaster BH, Kelley DE, Staten MA, Foster-Schubert KE, Cummings DE, Flum DR, Courcoulas AP, Havel PJ, Wolfe BM. Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass. Diabetologia. 2018 May;61(5):1142-1154. [PubMed]

Allister Price C, Argueta DA, Medici V, Bremer AA, Lee V, Nunez MV, Chen GX, Keim NL, Havel PJ, Stanhope KL, DiPatrizio NV. Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII and ApoE in humans consuming high fructose corn syrup-sweetened beverage. Am J Physiol Endocrinol Metab. 2018 Apr 10. [PubMed]

Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, Huypens P, Beckers J, de Angelis MH, Schürmann A, Bakhti M, Klingenspor M, Heiman M, Cherrington AD, Ristow M, Lickert H, Wolf E, Havel PJ, Müller TD, Tschöp MH. Animal models of obesity and diabetes mellitus. Nat Rev Endocrinol. 2018 Mar;14(3):140-162. [PubMed]

Ghoshal S, Stevens JR, Billon C, Girardet C, Sitaula S, Leon AS, Rao DC, Skinner JS, Rankinen T, Bouchard C, Nuñez MV, Stanhope KL, Howatt DA, Daugherty A, Zhang J, Schuelke M, Weiss EP, Coffey AR, Bennett BJ, Sethupathy P, Burris TP, Havel PJ, Butler AA. Adropin: An endocrine link between the biological clock and cholesterol homeostasis. Mol Metab. 2018 Feb;8:51-64. [PubMed]

Hung C, Bronec C, Napoli E, Graham J, Stanhope KL, Marsilio I, Giron MC, Havel PJ, Giulivi C. Adipose depot-specific effects of ileal interposition surgery in UCD-T2D rats: unexpected implications for obesity and diabetes. Biochem J. 2018 Feb 14;475(3):649-662. [PubMed]

Havel PJ, Kievit P, Comuzzie AG, Bremer AA. Use and Importance of Nonhuman Primates in Metabolic Disease Research: Current State of the Field. ILAR J. 2017 Dec 1;58(2):251-268. [PubMed]

López-Yoldi M, Stanhope KL, Garaulet M, Chen XG, Marcos-Gómez B, Carrasco-Benso MP, Santa Maria EM, Escoté X, Lee V, Nunez MV, Medici V, Martínez-Ansó E, Sáinz N, Huerta AE, Laiglesia LM, Prieto J, Martínez JA, Bustos M, Havel PJ, Moreno-Aliaga MJ. Role of cardiotrophin-1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice and characterization of 24-h circulating CT-1 profiles in normal-weight and overweight/obese subjects. FASEB J. 2017 Apr;31(4):1639-1649. [PubMed]

Hsu MF, Bettaieb A, Ito Y, Graham J, Havel PJ, Haj FG. Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria. Sci Rep. 2017 Mar 28;7(1):461. [PubMed]

Sato K, Okajima F, Miyashita K, Imamura S, Kobayashi J, Stanhope KL, Havel PJ, Machida T, Sumino H, Murakami M, Schaefer E, Nakajima K. The majority of lipoprotein lipase in plasma is bound to remnant lipoproteins: A new definition of remnant lipoproteins. Clin Chim Acta. 2016 Oct 1;461:114-25. [PubMed]

Stevens JR, Kearney ML, St-Onge MP, Stanhope KL, Havel PJ, Kanaley JA, Thyfault JP, Weiss EP, Butler AA. Inverse association between carbohydrate consumption and plasma adropin concentrations in humans. Obesity (Silver Spring). 2016 Aug;24(8):1731-40. [PubMed]

Aslibekyan S, Vaughan LK, Wiener HW, Hidalgo BA, Lemas DJ, O'Brien DM, Hopkins SE, Stanhope KL, Havel PJ, Thummel KE, Boyer BB, Tiwari HK. Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup'ik people. Genes Nutr. 2016 Aug 2;11:23. [PubMed]

Lemas DJ, Klimentidis YC, Aslibekyan S, Wiener HW, O'Brien DM, Hopkins SE, Stanhope KL, Havel PJ, Allison DB, Fernandez JR, Tiwari HK, Boyer BB. Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. Mol Nutr Food Res. 2016 Jul 28. [PubMed]

Green AJ, Graham JL, Gonzalez EA, La Frano MR, Petropoulou SE, Park JS, Newman JW, Stanhope KL, Havel PJ, La Merrill MA. Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats. Reprod Toxicol. 2016 Jul 12. pii: S0890-6238(16)30266-0. [PubMed] 

Piccolo BD, Graham JL, Stanhope KL, Fiehn O, Havel PJ, Adams SH. Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model. Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E958-69. [PubMed]

Fravel VA, Van Bonn W, Gulland F, Rios C, Fahlman A, Graham JL, Havel PJ. INTRAPERITONEAL DEXTROSE ADMINISTRATION AS AN ALTERNATIVE EMERGENCY TREATMENT FOR HYPOGLYCEMIC YEARLING CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS). J Zoo Wildl Med. 2016 Mar;47(1):76-82. [PubMed] 

Stanhope KL, Havel PJ. Response to "Best (but oft forgotten) practices: testing for treatment effects in randomized trials by separate analyses of changes from baseline in each group is a misleading approach". Am J Clin Nutr. 2016 Feb;103(2):589. doi: 10.3945/ajcn.115.125989. [PubMed]

Butler AA, St-Onge MP, Siebert EA, Medici V, Stanhope KL, Havel PJ. Differential Responses of Plasma Adropin Concentrations To Dietary Glucose or Fructose Consumption In Humans. Sci Rep 2015;5:14691. [PubMed]

Thomas S, Almers L, Schneider J, Graham JE, Havel PJ, Corley DA. Ghrelin and Leptin Have a Complex Relationship with Risk of Barrett's Esophagus. Dig Dis Sci 2015. [PubMed]

Stanhope KL, Medici V, Bremer AA, Lee V, Lam HD, Nunez MV, Chen GX, Keim NL, Havel PJ. A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults. Am J Clin Nutr 2015;101(6):1144-54. [PubMed]

Tryon MS, Stanhope KL, Epel ES, Mason AE, Brown R, Medici V, Havel PJ, Laugero KD. Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body. J Clin Endocrinol Metab 2015;100(6):2239-47. [PubMed]

Vaughan LK, Wiener HW, Aslibekyan S, Allison DB, Havel PJ, Stanhope KL, O'Brien DM, Hopkins SE, Lemas DJ, Boyer BB, Tiwari HK. Linkage and association analysis of obesity traits reveals novel loci and interactions with dietary n-3 fatty acids in an Alaska Native (Yup'ik) population. Metabolism 2015;64(6):689-97. [PubMed]

Hofmann SM, Havel PJ. The good, the bad, and the unknown: Fructose and FGF21. Mol Metab 2015;4(1):1-2. [PubMed]

Fields AJ, Berg-Johansen B, Metz LN, Miller S, La B, Liebenberg EC, Coughlin DG, Graham JL, Stanhope KL, Havel PJ, Lotz JC. Alterations in intervertebral disc composition, matrix homeostasis and biomechanical behavior in the UCD-T2DM rat model of type 2 diabetes. J Orthop Res 2015;33(5):738-46. [PubMed]

des Courtis X, Wei A, Kass PH, Fascetti AJ, Graham JL, Havel PJ, Ramsey JJ. Influence of dietary protein level on body composition and energy expenditure in calorically restricted overweight cats. J Anim Physiol Anim Nutr (Berl) 2015;99(3):474-82. [PubMed]

Blevins JE, Graham JL, Morton GJ, Bales KL, Schwartz MW, Baskin DG, Havel PJ. Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. Am J Physiol Regul Integr Comp Physiol 2015;308(5):R431-8. [PubMed]

Almers LM, Graham JE, Havel PJ, Corley DA. Adiponectin May Modify the Risk of Barrett's Esophagus in Patients With Gastroesophageal Reflux Disease. Clin Gastroenterol Hepatol Jan 2015. [PubMed]

Wei A, Fascetti AJ, Kim K, Lee A, Graham JL, Havel PJ, Ramsey JJ. Early effects of neutering on energy expenditure in adult male cats. PLoS One 2014;9(2):e89557. [PubMed]

O'Brien DM, Kristal AR, Nash SH, Hopkins SE, Luick BR, Stanhope KL, Havel PJ, Boyer BB. A stable isotope biomarker of marine food intake captures associations between n-3 fatty acid intake and chronic disease risk in a Yup'ik study population, and detects new associations with blood pressure and adiponectin. J Nutr 2014;144(5):706-13. [PubMed]

Nash SH, Kristal AR, Bersamin A, Choy K, Hopkins SE, Stanhope KL, Havel PJ, Boyer BB, O'Brien DM. Isotopic estimates of sugar intake are related to chronic disease risk factors but not obesity in an Alaska native (Yup'ik) study population. Eur J Clin Nutr 2014;68(1):91-6. [PubMed]

Laughlin MR, Bantle JP, Havel PJ, Parks E, Klurfeld DM, Teff K, Maruvada P. Clinical research strategies for fructose metabolism. Adv Nutr 2014;5(3):248-59. [PubMed]

Klimentidis YC, Lemas DJ, Wiener HH, O'Brien DM, Havel PJ, Stanhope KL, Hopkins SE, Tiwari HK,
Boyer BB. CDKAL1 and HHEX are associated with type 2 diabetes-related traits among Yup'ik people. J Diabetes 2014;6(3):251-9. [PubMed]

Cummings BP, Bettaieb A, Graham JL, Stanhope K, Haj FG, Havel PJ. Administration of pioglitazone alone or with alogliptin delays diabetes onset in UCD-T2DM rats. J Endocrinol 2014;221(1):133-44. [PubMed]

Campos GM, Rabl C, Havel PJ, Rao M, Schwarz JM, Schambelan M, Mulligan K. Changes in post-prandial glucose and pancreatic hormones, and steady-state insulin and free fatty acids after gastric bypass surgery. Surg Obes Relat Dis 2014;10(1):1-8. [PubMed]

Buss J, Havel PJ, Epel E, Lin J, Blackburn E, Daubenmier J. Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity? Appetite 2014;76:84-94. [PubMed]

Bremer AA, Stanhope KL, Graham JL, Cummings BP, Ampah SB, Saville BR, Havel PJ. Fish oil supplementation ameliorates fructose-induced hypertriglyceridemia and insulin resistance in adult male rhesus macaques. J Nutr 2014;144(1):5-11. [PubMed]

Aslibekyan S, Wiener HW, Havel PJ, Stanhope KL, O'Brien DM, Hopkins SE, Absher DM, Tiwari HK, Boyer BB. DNA methylation patterns are associated with n-3 fatty acid intake in Yup'ik people. J Nutr 2014;144(4):425-30. [PubMed]

Aschbacher K, Kornfeld S, Picard M, Puterman E, Havel PJ, Stanhope K, Lustig RH, Epel E. Chronic stress increases vulnerability to diet-related abdominal fat, oxidative stress, and metabolic risk. Psychoneuroendocrinology 2014;46:14-22. [PubMed]

Agrawal R, Zhuang Y, Cummings BP, Stanhope KL, Graham JL, Havel PJ, Gomez-Pinilla F. Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes. Biochim Biophys Acta 2014;1842(9):1313-23. [PubMed]

Stanhope KL, Schwarz JM, Havel PJ. Adverse metabolic effects of dietary fructose: results from the recent epidemiological, clinical, and mechanistic studies. Curr Opin Lipidol 2013;24(3):198-206.

Rozga MR, Stern JS, Stanhope K, Havel PJ, Kazaks AG. Dietary supplement users vary in attitudes and sources of dietary supplement information in East and West geographic regions: a cross-sectional study. BMC Complement Altern Med 2013;13(1):200.

Rountree AM, Reed BJ, Cummings BP, Jung SR, Stanhope KL, Graham JL, Griffen SC, Hull RL, Havel PJ, Sweet IR. Loss of coupling between calcium influx, energy consumption and insulin secretion associated with development of hyperglycaemia in the UCD-T2DM rat model of type 2 diabetes. Diabetologia 2013;56(4):803-13.

Rezvani R, Cianflone K, McGahan JP, Berglund L, Bremer AA, Keim NL, Griffen SC, Havel PJ, Stanhope KL. Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin, and adiponectin: Relationships with Metabolic Outcomes. Obesity (Silver Spring) 2013.

Miyashita K, Kobayashi J, Imamura S, Kinoshita N, Stanhope KL, Havel PJ, Nakajima K, Machida T, Sumino H, Nara M, Murakami M. A new enzyme-linked immunosorbent assay system for human hepatic triglyceride lipase. Clin Chim Acta 2013;424:201-6.

Medici V, Shibata NM, Kharbanda KK, LaSalle JM, Woods R, Liu S, Engelberg JA, Devaraj S, Torok NJ, Jiang JX, Havel PJ, Lonnerdal B, Kim K, Halsted CH. Wilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease. Hepatology 2013;57(2):555-65.

Klimentidis YC, Lemas DJ, Wiener HH, O'Brien DM, Havel PJ, Stanhope KL, Hopkins SE, Tiwari HK, Boyer BB. CDKAL1 and HHEX are associated with type-2 diabetes-related traits among Yup'ik people. J Diabetes 2013.

Hedderson MM, Darbinian J, Havel PJ, Quesenberry CP, Sridhar S, Ehrlich S, Ferrara A. Low Prepregnancy Adiponectin Concentrations Are Associated With a Marked Increase in Risk for Development of Gestational Diabetes Mellitus. Diabetes Care 2013.

Foster GA, Gower RM, Stanhope KL, Havel PJ, Simon SI, Armstrong EJ. On-chip phenotypic analysis of inflammatory monocytes in atherogenesis and myocardial infarction. Proc Natl Acad Sci U S A 2013;110(34):13944-9.

Cummings BP, Graham JL, Stanhope KL, Chouinard ML, Havel PJ. Maternal Ileal Interposition Surgery Confers Metabolic Improvements to Offspring Independent of Effects on Maternal Body Weight in UCD-T2DM Rats. Obes Surg 2013.

Cummings BP, Bremer AA, Kieffer TJ, D'Alessio D, Havel PJ. Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques. J Endocrinol 2013;216(2):207-15.

Cummings BP, Bettaieb A, Graham JL, Kim J, Ma F, Shibata N, Stanhope KL, Giulivi C, Hansen F, Jelsing J, Vrang N, Kowala M, Chouinard ML, Haj FG, Havel PJ. Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats. Dis Model Mech 2013;6(2):443-56.

Bremer AA, Stanhope KL, Graham JL, Cummings BP, Ampah SB, Saville BR, Havel PJ. Fish Oil Supplementation Ameliorates Fructose-Induced Hypertriglyceridemia and Insulin Resistance in Adult Male Rhesus Macaques. J Nutr 2013.

Bray M, Pomeroy J, Knowler WC, Bersamin A, Hopkins S, Brage SR, Stanhope K, Havel PJ, Boyer BB. Simple anthropometrics are more correlated with health variables than are estimates of body composition in Yup'ik people. Obesity (Silver Spring) 2013;21(9):E435-8.

Bettaieb A, Bakke J, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B, Graham J, Bremer A, Zhang S, Lyssiotis CA, Zhang ZY, Cantley LC, Havel PJ, Haj FG. Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. J Biol Chem 2013;288(24):17360-71.

Aslibekyan S, Vaughan LK, Wiener HW, Lemas DJ, Klimentidis YC, Havel PJ, Stanhope KL, O'Brien D M, Hopkins SE, Boyer BB, Tiwari HK. Evidence for novel genetic loci associated with metabolic traits in Yup'ik people. Am J Hum Biol 2013;25(5):673-80.

Yang RY, Havel PJ, Liu FT. Galectin-12: A protein associated with lipid droplets that regulates lipid metabolism and energy balance. Adipocyte 2012;1(2):96-100.

Tomiyama AJ, Schamarek I, Lustig RH, Kirschbaum C, Puterman E, Havel PJ, Epel ES. Leptin concentrations in response to acute stress predict subsequent intake of comfort foods. Physiol Behav 2012;107(1):34-9.

Stookey JD, Hamer J, Espinoza G, Higa A, Ng V, Tinajero-Deck L, Havel PJ, King JC. Orange juice limits postprandial fat oxidation after breakfast in normal-weight adolescents and adults. Adv Nutr 2012;3(4):629S-35S.

Rao MN, Schambelan M, Tai VW, Abrams DI, Khatami H, Havel PJ, Sakkas G, Mulligan K. Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men. AIDS Res Treat 2012;2012:103072.

Nagata N, Matsuo K, Bettaieb A, Bakke J, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Jung DY, Ramsey JJ, Kim JK, Cortopassi G, Havel PJ, Haj FG. Hepatic Src homology phosphatase 2 regulates energy balance in mice. Endocrinology 2012;153(7):3158-69.

Lemas DJ, Wiener HW, O'Brien DM, Hopkins S, Stanhope KL, Havel PJ, Allison DB, Fernandez JR, Tiwari HK, Boyer BB. Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos. J Lipid Res 2012;53(1):175-84.

Lee J, Cummings BP, Martin E, Sharp JW, Graham JL, Stanhope KL, Havel PJ, Raybould HE. Glucose sensing by gut endocrine cells and activation of the vagal afferent pathway is impaired in a rodent model of type 2 diabetes mellitus. Am J Physiol Regul Integr Comp Physiol 2012;302(6):R657-66.

Ishida T, Miyashita K, Shimizu M, Kinoshita N, Mori K, Sun L, Yasuda T, Imamura S, Nakajima K, Stanhope KL, Havel PJ, Hirata K. ELISA system for human endothelial lipase. Clin Chem 2012;58(12):1656-64.

Guglielmino K, Jackson K, Harris TR, Vu V, Dong H, Dutrow G, Evans JE, Graham J, Cummings BP, Havel PJ, Chiamvimonvat N, Despa S, Hammock BD, Despa F. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol 2012;303(7):H853-62.

Despa S, Margulies KB, Chen L, Knowlton AA, Havel PJ, Taegtmeyer H, Bers DM, Despa F. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circ Res 2012;110(4):598-608.

Daubenmier J, Lin J, Blackburn E, Hecht FM, Kristeller J, Maninger N, Kuwata M, Bacchetti P, Havel PJ, Epel E. Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study. Psychoneuroendocrinology 2012;37(7):917-28.

Cummings BP, Bettaieb A, Graham JL, Stanhope KL, Kowala M, Haj FG, Chouinard ML, Havel PJ. Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM rats. Endocrinology 2012;153(8):3620-32.

Cox CL, Stanhope KL, Schwarz JM, Graham JL, Hatcher B, Griffen SC, Bremer AA, Berglund L, McGahan JP, Keim NL, Havel PJ. Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans. Nutr Metab (Lond) 2012;9(1):68.

Cox CL, Stanhope KL, Schwarz JM, Graham JL, Hatcher B, Griffen SC, Bremer AA, Berglund L, McGahan JP, Havel PJ, Keim NL. Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women. Eur J Clin Nutr 2012;66(2):201-8.

Butler AA, Tam CS, Stanhope KL, Wolfe BM, Ali MR, O'Keeffe M, St-Onge MP, Ravussin E, Havel PJ. Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans. J Clin Endocrinol Metab 2012;97(10):3783-91.

Yang RY, Yu L, Graham JL, Hsu DK, Lloyd KC, Havel PJ, Liu FT. Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice. Proc Natl Acad Sci U S A 2011;108(46):18696-701.

Wei A, Fascetti AJ, Liu KJ, Villaverde C, Green AS, Manzanilla EG, Havel PJ, Ramsey JJ. Influence of a high-protein diet on energy balance in obese cats allowed ad libitum access to food. J Anim Physiol Anim Nutr (Berl) 2011;95(3):359-67.

Stanhope KL, Griffen SC, Bremer AA, Vink RG, Schaefer EJ, Nakajima K, Schwarz JM, Beysen C, Berglund L, Keim NL, Havel PJ. Metabolic responses to prolonged consumption of glucose- and fructose-sweetened beverages are not associated with postprandial or 24-h glucose and insulin excursions. Am J Clin Nutr 2011;94(1):112-9.

Stanhope KL, Bremer AA, Medici V, Nakajima K, Ito Y, Nakano T, Chen G, Fong TH, Lee V, Menorca RI, Keim NL, Havel PJ. Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women. J Clin Endocrinol Metab 2011;96(10):E1596-605.

Purnell JQ, Klopfenstein BA, Stevens AA, Havel PJ, Adams SH, Dunn TN, Krisky C, Rooney WD. Brain functional magnetic resonance imaging response to glucose and fructose infusions in humans. Diabetes Obes Metab 2011;13(3):229-34.

Nakajima K, Nakano T, Tokita Y, Nagamine T, Inazu A, Kobayashi J, Mabuchi H, Stanhope KL, Havel PJ, Okazaki M, Ai M, Tanaka A. Postprandial lipoprotein metabolism: VLDL vs chylomicrons. Clin Chim Acta 2011;412(15-16):1306-18.

Makhoul Z, Kristal AR, Gulati R, Luick B, Bersamin A, O'Brien D, Hopkins SE, Stephensen CB, Stanhope KL, Havel PJ, Boyer B. Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. Eur J Clin Nutr 2011;65(7):808-17.

Cummings BP, Bettaieb A, Graham JL, Stanhope KL, Dill R, Morton GJ, Haj FG, Havel PJ. Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats. Proc Natl Acad Sci U S A 2011;108(35):14670-5.

Cox CL, Stanhope KL, Schwarz JM, Graham JL, Hatcher B, Griffen SC, Bremer AA, Berglund L, McGahan JP, Keim NL, Havel PJ. Circulating concentrations of monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, and soluble leukocyte adhesion molecule-1 in overweight/obese men and women consuming fructose- or glucose-sweetened beverages for 10 weeks. J Clin Endocrinol Metab 2011;96(12):E2034-8.

Bremer AA, Stanhope KL, Graham JL, Cummings BP, Wang W, Saville BR, Havel PJ. Fructose-fed rhesus monkeys: a nonhuman primate model of insulin resistance, metabolic syndrome, and type 2 diabetes. Clin Transl Sci 2011;4(4):243-52.

Bauerly K, Harris C, Chowanadisai W, Graham J, Havel PJ, Tchaparian E, Satre M, Karliner JS, Rucker RB. Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats. PLoS One 2011;6(7):e21779.

Stanhope KL, Havel PJ. Fructose consumption: recent results and their potential implications. Ann N Y Acad Sci 2010;1190:15-24.

Medici V, Ali MR, Seo S, Aoki CA, Rossaro L, Kim K, Fuller WD, Vidovszky TJ, Smith W, Jiang JX, Maganti K, Havel PJ, Kamboj A, Ramsamooj R, Torok NJ. Increased soluble leptin receptor levels in morbidly obese patients with insulin resistance and nonalcoholic fatty liver disease. Obesity (Silver Spring) 2010;18(12):2268-73.

Cummings BP, Stanhope KL, Graham JL, Griffen SC, Havel PJ. Supplementation with EPA or fish oil for 11 months lowers circulating lipids, but does not delay the onset of diabetes in UC Davis-type 2 diabetes mellitus rats. Br J Nutr 2010;104(11):1628-34.

Cummings BP, Stanhope KL, Graham JL, Baskin DG, Griffen SC, Nilsson C, Sams A, Knudsen LB, Raun K, Havel PJ. Chronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM rats. Diabetes 2010;59(10):2653-61.

Adam T, Schamarek I, Springer EA, Havel PJ, Epel EE. Adiponectin and negative mood in healthy premenopausal and postmenopausal women. Horm Behav 2010;58(5):699-704.

Cummings, Bethany P., April D. Strader, Kimber L. Stanhope, James L. Graham, Jennifer Lee, Helen E. Raybould, Denis G. Baskin, and Peter J. Havel. Ileal interposition surgery increases circulating GLP-1 and PYY responses, improves glucose and lipid metabolism and delays diabetes onset in the UCD-T2DM rat. Gastroenterology. 2010;138(7):2437-46, 46 e1. [PubMed]

Cummings, Bethany P., Kimber L. Stanhope, James L. Graham, Joseph L. Evans, Denis G. Baskin, Steven C. Griffen, and Peter J. Havel. Dietary Fructose Accelerates the Development of Diabetes in UCD-T2DM Rats: Amelioration by the Antioxidant, _-Lipoic Acid. Am. J. Physiol. (Regul. Integrative Comp. Physiol.) 2010;298(5):R1343-50.[PubMed]

Asztalos, Bela F., Michael M. Swarbrick, Ernst J. Schaefer, Gerard E. Dallal, Katalin V. Horvath, Masumi Ai, Kimber L. Stanhope, Bruce M. Wolfe, Mohamed Ali, and Peter J. Havel. Effects of weight loss following gastric bypass surgery on HDL remodeling. J Lipid Res 2010;51(8):2405-12. [PubMed]

Stanhope, Kimber L., Nancy L. Keim, Steven C. Griffen, Andrew A. Bremer, James L. Graham, Bonnie Hatcher, Chad Cox, John P. McGahan, Anthony Seibert, Ronald M. Krauss Sally Chiu, Ernst J. Schaefer, Masumi Ai, Seiko Otokozawa, Katsuyuki Nakajima, Takamitsu Nakano, Carine Beysen, Jean Marc Schwarz, Marc K. Hellerstein, Lars Berglund, and Peter J. Havel. Effects of consuming fructose- or glucose-sweetened beverages for 10 weeks on lipids, insulin sensitivity, and adiposity. J. Clin. Invest. 119: 1322-1344, 2009.

Teff, Karen L. Joanne Grudziak, Raymond R. Townsend, Tamara N. Dunn, Sean H. Adams, Nancy L. Keim, Bethany P. Cummings, Kimber L. Stanhope, and Peter J. Havel. Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: Influence of insulin resistance on plasma triglyceride responses. J. Clin. Endocrinol. Metab., 94: 1562-1569, 2009. [PubMed]

Swarbrick, Michael M., Peter J. Havel, Arthur A. Levin, Kimber L. Stanhope, Madeline Butler, Sheri Booten, Robert A. Mckay, Susan F. Murray, Lynnetta M. Watts, Brett P. Monia, and Sanjay Bhanot. Inhibition of protein tyrosine phosphatase (PTP-1B) with antisense oligonucleotides improves insulin sensitivity and increases total adiponectin concentrations in monkeys. Endocrinology, 150: 1670-1679, 2009. [PubMed]

Cummings, Bethany P.  Erin K. Digitale, Kimber L. Stanhope, James L. Graham, Steven C. Griffen, and Peter J. Havel. Development and Characterization of a Novel Rodent Model of Type 2 Diabetes Mellitus: The UC Davis Type 2 Diabetes Mellitus (UCD-T2DM) Rat. Am. J. Physiol. (Regul. Integrative Comp. Physiol.) 285: R1782-R1793, 2008.

Swarbrick, Michael M., Iselin T. Austrheim-Smith, Kimber L. Stanhope, Marta D. Van Loan,  Mohamed R. Ali, Bruce M. Wolfe, and Peter J. Havel. Longitudinal changes of pancreatic and adipocyte hormones following Roux-en-Y gastric bypass surgery. Diabetologia, 51: 1901-1911, 2008.

Adams, Sean H., Kimber L. Stanhope, Ryan W. Grant, Bethany P. Cummings, and Peter J. Havel. Metabolic and endocrine profiles in response to systemic infusion of fructose and glucose in rhesus macaques. Endocrinology 149: 3002-3008, 2008. [PubMed]

Stanhope, Kimber L., Steven C. Griffen, Brandi Bair, Michael M. Swarbrick, Nancy L. Keim, and Peter J. Havel. Twenty-four hour endocrine and metabolic profiles following consumption of high fructose corn syrup-, sucrose- fructose-, and glucose-sweetened beverages with meals. Am. J. Clin. Nutr. 87: 1194-1203, 2008. [PubMed]

Maria J. Moreno-Aliaga, Michael M. Swarbrick, Kimber L. Stanhope, Peter J. Havel, and J. Alfredo Martínez.  Sp1-Mediatated transcription is involved in the induction of leptin by insulin-stimulated glucose metabolism. J. Mol. Endocrinol. 38: 537-546, 2007. [PubMed]

Swarbrick, Michael M., Iselin Austrheim-Smith, Kimber L. Stanhope, Marta Van Loan, Mohamed Ali, Bruce Wolfe, and Peter J. Havel. Circulating concentrations of high molecular weight adiponectin multimers increase following Roux-en-Y gastric bypass surgery. Diabetologia 49: 2552-2558, 2006. [PubMed]

Griffen, Steven C., Kimberly Oostema, Kimber L. Stanhope, James Graham, Dennis Styne, Nicole Glaser, David Cummings, Matthew Connors and Peter J. Havel.  Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin compared with regular/ NPH insulin in female patients with type-1 diabetes. J. Clin. Endocrinol. Metab. 91: 485-491, 2006. [PubMed]

Quinn, LeBris S., Lena Strait-Bodey, Josep M. Argilés, and Peter J. Havel. Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: Evidence for a skeletal muscle-to-fat signaling pathway. Cell Biology International 29: 449-457, 2005. [PubMed]

Teff, Karen, Sharon S. Elliott, Matthias Tschoep, Timothy J. Kieffer, Daniel Rader, Mark Heiman, Raymond R. Townsend, Nancy L. Keim, David D’Alessio and Peter J. Havel. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin and increases triglycerides in women. J. Clin. Endocrinol. Metab. 89: 2963-2972, 2004. [PubMed]

D’Alessio, David, Kieffer, Timothy J., Taborsky, Gerald J., and Peter J. Havel. Activation of the parasympathetic nervous system contributes to meal-induced insulin secretion in rhesus macaques. J. Clin. Endocrinol. Metab. 86: 1253-1259, 2001. [PubMed]

Ahren, Bo, and Peter J. Havel. Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic ß cell line (INS-1 cells). Am. J. Physiol. (Regulatory, Int., Comp. Physiol.) 277: R959-R966, 1999. [PubMed]

Ahren Bo, and Peter J. Havel. Leptin increases circulating glucose, insulin, and glucagon via sympathetic neural activation in fasted mice. Int. J. Obesity 23: 660-665, 1999. [PubMed]

Havel, Peter J., Townsend, Raymond, Chaump, Leslie, and Karen Teff. High fat meals reduce 24 h circulating leptin concentrations in women. Diabetes 48: 334-341, 1999.   [PubMed]

Keim, Nancy L., Stern, Judith S., and Peter J. Havel. Relationship between circulating leptin concentrations and appetite during prolonged moderate energy restriction in women. Am. J. Clin. Nutr.  68: 794-801, 1998.

Havel, Peter J., Uriu-Hare, Janet Y., Liu, Tina, Stanhope, Kimber L., Stern, Judith S., Keen, Carl L., and Bo Ahren. Rapid and marked decreases of circulating leptin in streptozotocin diabetic rats: Reversal by insulin. Am. J. Physiol. 274: R1482-R1491, 1998. [PubMed]

Mueller, Wendy, Gregoire, Francine, Stanhope, Kimber, Mobbs, Charles V., Mizuno, Tooru M., Warden, Craig H., Stern, Judith S., and Peter J. Havel. Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology 139: 551-558, 1998. [PubMed]

Book Chapters and Review Articles:

Havel, Peter J. and Andrew A. Bremer. Endocrine Regulation of Energy Homeostasis: Implications for Obesity and Diabetes. In: Obesity. Eds. M. S. Ríos, J. M. Ordovás & J. A. Gutiérrez-Fuentes. McGraw Hill, In Press, 2010.

Stanhope, Kimber L. and Peter J. Havel. Fructose consumption: Recent results and their potential implications. Ann. New York Acad. Sci., 1190: 15-24, 2010. [PubMed]

Stanhope, Kimber L. and Peter J. Havel. Fructose consumption: Considerations for future research of its effects on adipose distribution, lipid metabolism and insulin sensitivity in humans. J. Nutr., 139: 1236S-1241S, 2009. [PubMed]

Swarbrick, Michael M. and Peter J. Havel. Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans. Metabolic Syndrome and Related Disorders, 6: 87-102, 2008. [PubMed]

Stanhope, Kimber L. and Peter J. Havel. Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high fructose corn syrup. Am. J. Clin. Nutr. 88: 1733S-1737S, 2008. [PubMed]

Stanhope, Kimber L. and Peter J. Havel. Fructose Consumption: Potential Mechanisms for its Effects to Increase Visceral Adiposity and Induce Dyslipidemia and Insulin Resistance. Current Opinion in Lipidology 19: 16-24, 2008. [PubMed]

Havel, Peter J. Dietary Fructose: Implications for Dysregulation of Energy Homeostasis and Lipid/Carbohydrate Metabolism. Nutrition Reviews 63: 133-157, 2005. [PubMed]

Keim, Nancy L, Roy J. Levin, and Peter J. Havel. Carbohydrates p 62-82. In: Modern Nutrition in Health and Disease (10th Edition). Ed. A.C. Ross. Lippincott, Williams, & Wilkins, 2005.

Havel. Peter J.  Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/ Lipid Metabolism. Diabetes 53 (Suppl. 1):S143-S151, 2004. [PubMed]