Angela M. Zivkovic, Ph.D.

Education

• B.S., Conservation & Resource Studies, University of, California Berkeley
• Ph.D., Nutritional Biology, University of California, Davis

Research Interests

Dr. Zivkovic’s research is focused on the role of diet and nutrition in Precision Health. Precision Health emphasizes individually tailored approaches to optimize health and prevent disease. The Zivkovic Lab has four overall research themes: 1) Investigating the functional biology of HDL; 2) Assessing the effects of diets and dietary constituents on inflammation; 3) Integrating clinical, metabolomic, proteomic, glycomic, transcriptomic, and genomic approaches to characterize metabolic phenotypes and their responsiveness to different diets; and 4) Investigating the effects of diets and dietary constituents on the gut microbiota and how they in turn affect host health.

Lab: http://zivkoviclab.ucdavis.edu/

Selected Publications

Rodriguez A, Trigatti BL, Mineo C, Knaack D, Wilkins JT, Sahoo D, Asztalos BF, Mora S, Cuchel M, Pownall HJ, Rosales C, Bernatchez P, Ribeiro Martins da Silva A, Getz GS, Barber JL, Shearer GC, Zivkovic AM, Tietge UJF, Sacks FM, Connelly MA, Oda MN, Davidson WS, Sorci-Thomas MG, Vaisar T, Ruotolo G, Vickers KC, Martel C. Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2019 Oct 10. [PubMed]

Chenghao Zhu, Maurice Wong, Qiongyu Li, Lisa Sawrey-Kubicek, Elizabeth Beals, Chris H. Rhodes, Romina Sacchi, Carlito B. Lebrilla, and Angela M. Zivkovic. Site-Specific Glycoprofiles of HDL-Associated ApoE are Correlated with HDL Functional Capacity and Unaffected by Short-Term Diet. Journal of Proteome Research. 2019 Sep 23. [Article]

Sawrey-Kubicek L, Zhu C1, Bardagjy AS, Rhodes CH, Sacchi R, Randolph JM, Steinberg FM, Zivkovic AM. Whole egg consumption compared with yolk-free egg increases the cholesterol efflux capacity of high-density lipoproteins in overweight, postmenopausal women. Am J Clin Nutr. 2019 Sep 1;110(3):617-627 [PubMed]

Zhu C, Sawrey-Kubicek L, Beals E, Hughes RL, Rhodes CH, Sacchi R, Zivkovic AM.The HDL lipidome is widely remodeled by fast food versus Mediterranean diet in 4 days. Metabolomics. 2019 Aug 17;15(8):114. [PubMed]

Clotilde Théry, Kenneth W Witwer, Elena Aikawa, Maria Jose Alcaraz, Johnathon D Anderson, Ramaroson Andriantsitohaina, Angela M Zivkovic, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of Extracellular Vesicles. 23 Nov 2018. [Article]

Kailemia MJ, Wei W, Nguyen K, Beals E, Sawrey-Kubicek L, Rhodes C, Zhu C, Sacchi R, Zivkovic AM, Lebrilla CB. Targeted Measurements of O- and N-Glycopeptides Show That Proteins in High Density Lipoprotein Particles Are Enriched with Specific Glycosylation Compared to Plasma. J Proteome Res. 2018 Feb 2;17(2):834-845. [PubMed]

Rogers TS, Demmer E, Rivera N, Gertz ER, German JB, Smilowitz JT, Zivkovic AM, Van Loan MD. The role of a dairy fraction rich in milk fat globule membrane in the suppression of postprandial inflammatory markers and bone turnover in obese and overweight adults: an exploratory study. Nutr Metab (Lond). 2017 May 17;14:36. [PubMed]

O’Sullivan A, Henrick B, Dixon B, Barile D, Zivkovic A, Smilowitz J, Lemay D, Martin W, German JB, Schaefer SE. 21st Century Toolkit for Optimizing Population Health through Precision Nutrition. Crit Rev Food Sci Nutr. 2017 Jul 5:0. [PubMed]

Krishnan S, Shimoda M, Sacchi R, Kailemia MJ, Luxardi G, Kaysen GA, Parikh AN, Ngassam VN, Johansen K, Chertow GM, Grimes B, Smilowitz JT, Maverakis E, Lebrilla CB, Zivkovic AM. HDL Glycoprotein Composition and Site-Specific Glycosylation Differentiates Between Clinical Groups and Affects IL-6 Secretion in Lipopolysaccharide-Stimulated Monocytes. Sci Rep. 2017 Mar 13;7:43728. [Article]

Davis JC, Lewis ZT, Krishnan S, Bernstein RM, Moore SE, Prentice AM, Mills DA, Lebrilla CB, Zivkovic AM. Growth and Morbidity of Gambian Infants are Influenced by Maternal Milk Oligosaccharides and Infant Gut Microbiota. Sci Rep. 2017 Jan 12;7:40466. [PubMed]

Zeng NF, Mancuso JE, Zivkovic AM, Smilowitz JT, Ristenpart WD. Red Blood Cells from Individuals with Abdominal Obesity or Metabolic Abnormalities Exhibit Less Deformability upon Entering a Constriction. PLoS One. 2016 Jun 3;11(6):e0156070. PubMed

Demmer E, Van Loan MD, Rivera N, Rogers TS, Gertz ER, German JB, Smilowitz JT, Zivkovic AM. Addition of a dairy fraction rich in milk fat globule membrane to a high-saturated fat meal reduces the postprandial insulinaemic and inflammatory response in overweight and obese adults. J Nutr Sci. 2016 Mar 7;5:e14. [PubMed]

Demmer E, Van Loan MD, Rivera N, Rogers TS, Gertz ER, German JB, Zivkovic AM, Smilowitz JT. Consumption of a high-fat meal containing cheese compared with a vegan alternative lowers postprandial C-reactive protein in overweight and obese individuals with metabolic abnormalities: a randomised controlled cross-over study. J Nutr Sci. 2016 Feb 9;5:e9. [PubMed]

Karimpour M, Surowiec I, Wu J, Gouveia-Figueira S, Pinto R, Trygg J, Zivkovic AM, Nording ML. Postprandial metabolomics: A pilot mass spectrometry and NMR study of the human plasma metabolome in response to a challenge meal. Anal Chim Acta. 2016 Feb 18;908:121-31. doi: 10.1016/j.aca.2015.12.009. Epub 2015 Dec 17. [PubMed]

Berthelot CC, Kamita SG, Sacchi R, Yang J, Nording ML, Georgi K, Hegedus Karbowski C, German JB, Weiss RH, Hogg RJ, Hammock BD, Zivkovic AM. Changes in PTGS1 and ALOX12 Gene Expression in Peripheral Blood Mononuclear Cells Are Associated with Changes in Arachidonic Acid, Oxylipins, and Oxylipin/Fatty Acid Ratios in Response to Omega-3 Fatty Acid Supplementation. PLoS One. 2015 Dec 16;10(12):e0144996. [PubMed]

Wu J, Gouveia-Figueira S, Domellöf M, Zivkovic AM, Nording ML.  Oxylipins, endocannabinoids, and related compounds in human milk: levels and effects of storage conditions. Prostaglandins Other Lipid Mediat. 2015 Dec 2. pii: S1098-8823(15)30017-4. [PubMed]

Wu J, Domellöf M, Zivkovic AM, Larsson G, Öhman A, Nording ML.  NMR-based metabolite profiling of human milk: A pilot study of methods for investigating compositional changes during lactation. Biochem Biophys Res Commun. 2015 Dec 2. pii: S0006-291X(15)30983-9.[PubMed]

Krishnan S, Huang J, Lee H, Guerrero A, Berglund L, Erdembileg A, Lebrilla CB, Zivkovic AM. Combined HDL proteomic and glycomic profiles in patients at risk for coronary artery disease. J Proteome Res. 2015 Nov 4.  [PubMed]

Gouveia-Figueira S, Späth J, Zivkovic AM, Nording ML. Profiling the Oxylipin and Endocannabinoid Metabolome by UPLC-ESI-MS/MS in Human Plasma to Monitor Postprandial Inflammation. PLoS One. 2015 Jul 17;10(7):e0132042.  [PubMed]

Lang JM, Eisen JA, Zivkovic AM. The microbes we eat: abundance and taxonomy of microbes consumed in a day's worth of meals for three diet types. PeerJ. 2014;2:e659. [PubMed]

Huang J, Lee H, Zivkovic AM, Smilowitz JT, Rivera N, German JB, Lebrilla CB. Glycomic analysis of high density lipoprotein shows a highly sialylated particle. Journal of proteome research. 2014 Feb 7;13:681-91. [PubMed]

Smilowitz JT, Zivkovic AM, Wan YJ, Watkins SM, Nording ML, Hammock BD, German JB. Nutritional lipidomics: molecular metabolism, analytics, and diagnostics. Mol Nutr Food Res 2013;57(8):1319-35. [PubMed]

Nording ML, Yang J, Georgi K, Hegedus Karbowski C, German JB, Weiss RH, Hogg RJ, Trygg J, Hammock BD, Zivkovic AM. Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids. PLoS One 2013;8(10):e76575. [PubMed]

Zivkovic AM, Yang J, Georgi K, Hegedus C, Nording ML, O'Sullivan A, German JB, Hogg RJ, Weiss RH, Bay C, Hammock BD. Serum oxylipin profiles in IgA nephropathy patients reflect kidney functional alterations. Metabolomics 2012;8(6):1102-13. [PubMed]

Totten SM, Zivkovic AM, Wu S, Ngyuen U, Freeman SL, Ruhaak LR, Darboe MK, German JB, Prentice AM, Lebrilla CB. Comprehensive profiles of human milk oligosaccharides yield highly sensitive and specific markers for determining secretor status in lactating mothers. J Proteome Res 2012;11(12):6124-33. [PubMed]

Nwosu CC, Aldredge DL, Lee H, Lerno LA, Zivkovic AM, German JB, Lebrilla CB. Comparison of the human and bovine milk N-glycome via high-performance microfluidic chip liquid chromatography and tandem mass spectrometry. J Proteome Res 2012;11(5):2912-24. [PubMed]

Hua S, Nwosu CC, Strum JS, Seipert RR, An HJ, Zivkovic AM, German JB, Lebrilla CB. Site-specific protein glycosylation analysis with glycan isomer differentiation. Anal Bioanal Chem 2012;403(5):1291-302. [PubMed]

Zivkovic AM, German JB, Lebrilla CB, Mills DA. Human milk glycobiome and its impact on the infant gastrointestinal microbiota. Proc Natl Acad Sci U S A 2011;108 Suppl 1:4653-8. [PubMed]

Zivkovic AM, Barile D. Bovine milk as a source of functional oligosaccharides for improving human health. Adv Nutr 2011;2(3):284-9. [PubMed]

Nwosu CC, Seipert RR, Strum JS, Hua SS, An HJ, Zivkovic AM, German BJ, Lebrilla CB. Simultaneous and extensive site-specific N- and O-glycosylation analysis in protein mixtures. J Proteome Res 2011;10(5):2612-24. [PubMed]

German JB, Zivkovic AM, Dallas DC, Smilowitz JT. Nutrigenomics and personalized diets: What will they mean for food? Annu Rev Food Sci Technol 2011;2:97-123. [PubMed]

Froehlich JW, Barboza M, Chu C, Lerno LA, Jr., Clowers BH, Zivkovic AM, German JB, Lebrilla CB. Nano-LC-MS/MS of glycopeptides produced by nonspecific proteolysis enables rapid and extensive site-specific glycosylation determination. Anal Chem 2011;83(14):5541-7. [PubMed]

Dallas DC, Martin WF, Strum JS, Zivkovic AM, Smilowitz JT, Underwood MA, Affolter M, Lebrilla CB, German JB. N-linked glycan profiling of mature human milk by high-performance microfluidic chip liquid chromatography time-of-flight tandem mass spectrometry. J Agric Food Chem 2011;59(8):4255-63. [PubMed]

Bricarello DA, Smilowitz JT, Zivkovic AM, German JB, Parikh AN. Reconstituted lipoprotein: a versatile class of biologically-inspired nanostructures. ACS Nano 2011;5(1):42-57. [PubMed]

Smilowitz JT, German JB, Zivkovic AM. Food Intake and Obesity: The Case of Fat in "Fat Detection: Taste, Texture, and Post Ingestive Effects" Boca Raton FL: Taylor & Francis Group, LLC, 2010. [PubMed]

Argov-Argaman N, Smilowitz JT, Bricarello DA, Barboza M, Lerno L, Froehlich JW, Lee H, Zivkovic AM, Lemay DG, Freeman S, Lebrilla CB, Parikh AN, German JB. Lactosomes: Structural and Compositional Classification of Unique Nanometer-Sized Protein Lipid Particles of Human Milk. J Agric Food Chem 2010. [PubMed]

Zivkovic AM, Wiest MM, Nguyen UT, Davis R, Watkins SM, German JB. Effects of sample handling and storage on quantitative lipid analysis in human serum. Metabolomics 2009;5(4):507-16. [PubMed]

Zivkovic AM, Wiest MM, Nguyen U, Nording ML, Watkins SM, German JB. Assessing individual metabolic responsiveness to a lipid challenge using a targeted metabolomic approach. Metabolomics 2009;5(2):209-18. [PubMed]

Zivkovic AM, German JB. Metabolomics for assessment of nutritional status. Curr Opin Clin Nutr Metab Care 2009;12(5):501-7. [PubMed]

Zivkovic AM, Bruce German J, Esfandiari F, Halsted CH. Quantitative lipid metabolomic changes in alcoholic micropigs with fatty liver disease. Alcohol Clin Exp Res 2009;33(4):751-8. [PubMed]

Zivkovic AM, German JB, Sanyal AJ. Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease. Am J Clin Nutr 2007;86(2):285-300. [PubMed]

Zivkovic AM, German JB. Individual variation in the metabolic syndrome: a new perspective on the debate. Am J Clin Nutr 2007;85(1):240-1; author reply 1-2. [PubMed]

Lemay DG, Zivkovic AM, German JB. Building the bridges to bioinformatics in nutrition research. Am J Clin Nutr 2007;86(5):1261-9. [PubMed]

German JB, Gillies LA, Smilowitz JT, Zivkovic AM, Watkins SM. Lipidomics and lipid profiling in metabolomics. Curr Opin Lipidol 2007;18(1):66-71. [PubMed]

German JB, Smilowitz JT, Zivkovic AM. Lipoproteins: When size really matters. Curr Opin Colloid Interface Sci 2006;11(2-3):171-83. [PubMed]